今、世界が注目する医学論文は？
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、①クローン病（CD）の管理における部分経腸栄養療法（PEN）の役割を評価した結果a)、②クローン病（CD）における糞便移植療法（FMT）の寛解導入の有効性と安全性を評価した結果b)、③遠隔モニタリングが活動性炎症性腸疾患(IBD)患者の寛解期間とQOL (quality of life)を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2024年11月30日～12月5日まで）
-2025.2.28
今回は、①クローン病(CD)による狭窄に対する治療として、炎症が強力にコントロールされた条件下で、複数回の内視鏡的バルーン拡張術(EBD)とニードルナイフ狭窄切開術(NKSt)を実施することが、より有効な治療法であるかを評価した結果a)、②修正デルファイ法を用いた炎症性腸疾患(IBD)のコアアウトカムセットの定義b)、③IBD患者および健常対照者における血中の血管内皮増殖因子(VEGF)濃度を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2024年11月22日～11月29日まで）
-2025.2.27
2025.1.31 IBD
a) Eosinophils and risk of ulcerative colitis in European population: Evidence from Mendelian randomization study
b) Therapeutic and Immunologic Effects of Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review
c) Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins
2025.1.31 IBD
a) The association between bilirubin concentrations and inflammatory bowel disease: Insights from a systematic review and meta-analysis
b) Meta-analysis: Risk of lymphoma in patients with inflammatory bowel disease in population-based cohort studies
c) Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis
2024.12.24 IBD
a) Harms with placebo in trials of biological therapies and small molecules as induction therapy in inflammatory bowel disease: a systematic review and meta-analysis
b) Harms with placebo in trials of biological therapies and small molecules as maintenance therapy in inflammatory bowel disease: a systematic review and meta-analysis
c) Rates of Endoscopic Recurrence In Postoperative Crohn's Disease Based on Anastomotic Techniques: A Systematic Review And Meta-Analysis
2024.12.09 IBD
a) Comparing the Diagnostic Value of FDG PET or PET/CT with FDG PET/MR in Inflammatory Bowel Disease-A Systematic Review and Meta-analysis
b) The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study
c) Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis
2024.11.27 IBD
a) Chronic Kidney Disease in Inflammatory bowel disease: a Systematic Review and Meta-analysis
b) Prevalence of Sexual Dysfunction In Inflammatory bowel disease: Systematic Review and Meta-Analysis
c) Emerging role of environmental pollutants in Inflammatory bowel disease risk, outcomes and underlying mechanisms
2024.11.12 IBD
a) A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
b) Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease
c) Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials
2024.10.21 IBD
a) Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
b) Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease
c) Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
2024.10.04 IBD
a) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course
b) Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease
c) Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis