今、世界が注目する医学論文は？
<p><span style="font-family:'Noto Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';">インパクトファクターの高いジャーナルから、世界の研究者が注目する主に疾患に関する論文をご紹介します。</span></p>
今回は、プラセボ対照無作為化試験における、潰瘍性大腸炎(UC)やクローン病(CD)における新規薬剤の評価におけるプラセボ投与のリスクに関して①寛解導入を目的とした試験a)、②寛解維持を目的とした試験b)において評価した結果、③クローン病における回結腸吻合の術式の違いが内視鏡的術後再発(ePOR)に及ぼす影響を評価した結果c)、に関する以下の報告が注目を集めた。
（検索期間：2024年10月10日～10月24日まで）
-2024.12.24
2024.12.09 IBD
a) Comparing the Diagnostic Value of FDG PET or PET/CT with FDG PET/MR in Inflammatory Bowel Disease-A Systematic Review and Meta-analysis
b) The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study
c) Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis
2024.11.27 IBD
a) Chronic Kidney Disease in Inflammatory bowel disease: a Systematic Review and Meta-analysis
b) Prevalence of Sexual Dysfunction In Inflammatory bowel disease: Systematic Review and Meta-Analysis
c) Emerging role of environmental pollutants in Inflammatory bowel disease risk, outcomes and underlying mechanisms
2024.11.12 IBD
a) A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice
b) Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease
c) Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials
2024.10.21 IBD
a) Effect of mesenteric sparing or extended resection in primary ileocolic resection for Crohn's disease on postoperative endoscopic recurrence (SPICY): an international, randomised controlled trial
b) Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease
c) Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis
2024.10.04 IBD
a) Fungal Microbiota Composition in Inflammatory Bowel Disease Patients: Characterization in Different Phenotypes and Correlation With Clinical Activity and Disease Course
b) Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal CRTAM and PLCB1 as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn’s Disease
c) Early Biologic Treatment Decreases Risk of Surgery in Crohn’s Disease but not in Ulcerative Colitis: Systematic Review and Meta-Analysis